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Could a blind fighter do it? I'm thinking that sharingan relies on sight so a fighter that opts to use his other senses instead could stand a chance.
Itachis sharingan is unlike Sasukes or Kakashis. He has fully mastered Sharingan, he has a move called Mange Sharingan, where if you even come in to contact with his eyes he can basically mentally torture you to death.
He can do hand seals so fast that even Kakashi can not see him do them.
He beat Kakashi,Kurenai, and Gai without getting a finger laid on him.
A blind person would just get there ass beaten physically, since chances are that Itachi is as fast if not faster than Gai.
And god only knows how many Jutus he has copied over the years. Even in the manga he has not fought anyone seriously yet, so nobody knows what he is capable of.